University Publications

The aim of the current study was to investigate the protective and therapeutic effects of Zamzam water on inducing hyperglycemic Wistar rats. Rats classified into DZZ, DTZ, DTT, NTT, and NZZ groups after 2 weeks adaptation. Blood glucose was measured after alloxan induced hyperglycemia using a glucometer. Rats were sacrificed blood was collected, liver and kidney tissue were obtained. Blood glucose, ALT, AST, urea, and creatinine were measured using spectrophotometry method. CBC was estimated using full blood count analyzer. Sections of liver and kidney were stained using hematoxylin stain. The results showed that the treated group with DZZ and DTZ significantly decreased blood glucose levels than control. While a significant increase was observed in urea and creatinine of treaded DZZ group. Results of histopathological section revealed no alteration. The study concludes that Zamzam water had potential protective and treatment effect on alloxan induced hyperglycemia. Higher pH, calcium, and magnesium might make it is protective and treatment effect, since their role in insulin secretion and carbohydrate metabolism.