University Publications

The aim of the present study is to investigate the relationship of risk factors and cardiac biomarkers level with the development of cardiovascular disease (CVDs) in type-2 diabetic Palestinian patients in Gaza strip. Methodology; Study population consists of three groups: control (group 1); (group 2) with an equal number of diabetic type-2 without Cardio Vascular disease “CVD”. Both groups were attending Al- Remal central clinic. (group 3) are diabetic type-2 at the Cardio Care Unit (CCU) at El- Shifa hospital, Gaza. The study was conducted at the laboratory of Central laboratory in Remal Clinic, Gaza Strip-Palestine from June to October 2018 and included 180 subjects divided to the three equal groups: control, Type-2 Diabetic Patients “T2DM” an T2DM with CVD, age of the three groups was 45 – 65yrs. A questionnaire and vacationer serum blood samples were collected from all participants for the laboratory analysis. Results: The results revealed a significant difference between the three studied groups in the gender (P < 0.05), BMI, smoking, and level of hypertension “systolic/diastolic” significant difference (P< 0.01). As for the age, there was no significant difference among studied groups. A statistical significant difference (P<0.01) was clear between diabetes duration and CVD complication in “T2DM” patients, also for age at onset of DM for T2DM without CVDs groups and for T2DM with CVDs groups; (P<0.05). Significant difference was evident in the level of serum Lactate Dehydrogenase LDH, Creatine Kinase “CK”, Creatine Kinase Muscle Brain, Creatine Kinase Muscle Brain “CKMB” and Terminal Brain Natriuretic Peptide “NT-BNP” among three studied groups (P<0.01). Conclusion: There are many risk factors that have effect on cardiovascular disease in T2DM; using cardiac biomarkers that may aid in the early diagnostic and prognostic evaluation of high risk patients with T2DM to avoid complication to CVDs.