University Publications

Background: Anemia is one of the most common comorbidities associated chronic kidney disease (CKD) and is precipitated by multiple mechanisms including but not limited to: 1) decline in endogenous erythropoietin production in kidneys1, 2, 2) shortened erythrocyte survival3 3) nutritional deficiencies (folate, vitamin B12)4, iron is essential for hemoglobin formation and productive erythropoiesis, accurately assessing iron status is a prerequisite for diagnosing iron deficiency, monitoring the response to iron supplementation, and maintaining effective erythropoiesis in these patients. Objectives: The aim of this study is to assess iron profile in patient with CKD undergoing hemodialysis and to correlate iron profile result with patient’s age, gender and duration of dialysis. Materials and Methods: A descriptive analytical case control study was performed in five hemodialysis centers in Khartoum, Sudan. A total of 280 Sudanese were enrolled in this study (140 CKD patients under hemodialysis and 140 healthy controls), 81 (57.9%) were male and 59 (42.1%) were females, their age ranged between 20 to 85 years. Serum iron, saturated transferrin and total iron binding capacity (TIBC) were measured using Biosystem 350 semi-automated spectrophotometer and serum ferritin was measured using Roche Elecsys 2010. Data were analyzed by using statistical package for social sciences (SPSS) version 21. Results: The present study showed that serum iron of those under dialysis were significantly lower compared to control ( p value =0.00), serum ferritin of those under hemodialysis patient were significantly higher compared to control group (P value 0.00) .Also TIBC and transferrin saturation were significantly lower compared to control group (p value 0.018 and 0.00) respectively.