University Publications

Previous studies showed the link between hyperhomocysteinemia (HHcy), dyslipidemia, and Atherosclerosis among End stage renal disease. However, there was limited epidemic data concerning Sudanese patient and risk associated with hyperhomocsteinemia. This study aims to investigate the association of plasma homocysteine (Hcy) level with lipid profiles in End stage renal disease compare to control group. A total of 120 Sudanese subjects from a cohort of the Khartoum state were included in the analysis. Plasma total Hcy, serum lipid files including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were measured to evaluate associations of Hcy and lipid profiles in ESRD and control group. Subjects were 47.18 ± 8.91 years old, and 58.33% were male. Median Hcy was 21.85 ± 1.8 μmol/L for patients, and 12.11± 0.9 for healthy individuals. HHcy was associated with increasing risk of low HDL-C (HDL-C < 50 mg/dL; and hypertriglyceridemia (TG ≥ 150 mg/dL, there were significant different association between HHcy and TC or LDL-C. The present study showed that HHcy was associated with hypertriglyceridemia and low levels of HDL-C in end stage renal disease compare to healthy individual group, which provides evidence that Hcy levels might affect HDL-C and TG metabolism and may increase risk factor for developing cardiovascular diseases.